‘I would put a lot of money on saying that the next generation will have a completely different view of dementia disorders,’ says Professor Bart De Strooper

This is a quote from the head of Britains new £250 million Dementia Research Institute.

He predicts that Alzheimer’s may become as manageable as HIV/Aids in some cases by 2025, he hopes to see a time in the near future when even if the condition proves impossible to cure, it can at least be stabilised.

Professor De Strooper believes there is even a chance the brain could re-wire itself and restore lost mental ability once the progress of the disease has been halted.

Speaking after the announcement of his appointment as director of the £250 million UK DRI, the world-renowned Belgian neuroscientist told the Press Association: “We won’t be celebrating in 2025 that dementia is cured, but I hope that by then there will be groups of patients who can be treated in much the same way HIV-Aids is treated today.

“I believe it will happen. I’m very optimistic – the brain is the most plastic organ we have. If you could stabilise the disease at an early stage it might be possible to regain part of the function that seems to be lost.”

The Professor is building a team of multi-disciplinary doctors, biologists, engineers and data specialists who will be working from centres across the uk said he hope to see “real surprises”.

He added: “I’m a scientist so I don’t look into crystal balls but I would put a lot of money on saying that the next generation will have a completely different view of dementia disorders.

“In just the same way Aids in the 1970s and 80s was seen as a terrible doom or punishment of the gods, but is now manageable and treatable. Cancer has gone through a similar process – the way we look at cancer today is quite different from what it was a generation ago.

Professor Bart De Strooper

Professor Bart De Strooper

“I think we are already further on than many people believe.”

In a key shift to previous approaches he intends to broaden research beyond the “amyloid hypothesis” on which so much work up until now has focused.

The hypothesis places clumps of sticky protein fragments in the brain known as beta-amyloid at the heart of Alzheimer’s.

Beta-amyloid “plaques” are recognised as a key hallmark of the disease, but precisely what their role is remains unclear.

Prof De Strooper said: “The amyloid hypothesis is an old hypothesis from 25 years ago. Since then we have acquired so much information that can’t fit into the simple amyloid hypothesis.

“It would be an over-simplification to reduce Alzheimer’s to amyloid. The main problem is not that the hypothesis is untrue, but it is very old-fashioned, simplistic and linear.

“Dementia is likely to be much more complicated, in a similar way to cancer, which we now know is caused and driven by a multitude of factors. I hope progress in tackling dementia will go faster than it did with cancer.

“At the Institute we will approach dementia as a complicated, multi-factorial disease. Inflammation, biochemistry, cellular changes – all these things are likely to have an influence.

“It’s very difficult to imagine how you would replace parts of the brain that are gone but if we understand the process better it might be possible to interfere when the process is at the start. If we could step in 10 years before massive damage to the brain occurs, it would be a very nice thing.”

Prof De Strooper added: “My priority in the first year will be to improve our mechanistic understanding of the disease. We’ll be taking a multi-disciplinary approach to the problem.

“Modern medicine is already inherently multi-disciplinary, taking in areas such as genetics, bio-informatics and imaging. I’ll be talking to engineers, medical doctors, biologists. We’ll be moving from cell cultures to humans and back again.”

He stressed that the Institute would not just be looking at Alzheimer’s but would investigate the whole range of neurodegenerative diseases, including disorders such as Parkinson’s and Huntington’s. It would also search for common factors linking the conditions.

Press Association